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Global Flow Cytometry Markets

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Publication Date:
March 2016; Pages: 166
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Global Flow Cytometry Sample

Flow cytometry is a laboratory analytical technique that can rapidly measure multiple parameters of individual cells or particles as they pass through a beam of light, typically a laser. The global flow cytometry market remains one of the fastest-growing segments of life sciences and clinical diagnostics markets. In the current life sciences research, pharmaceutical drug discovery and development, and clinical diagnostics markets, flow cytometry offers some of the brightest promise for growth and innovation. The purpose of this TriMark Publications report is to provide a detailed analysis of the global flow cytometry market, including size, growth, technology platforms, applications, new instrumentation, industry trends and the internal structure of the sector. The study covers highly attractive growth areas such as stem cell research, biomarkers and companion diagnostics, CD4 testing, high throughput screening and immunology and vaccine development. It also analyzes almost all of the companies known to be marketing, manufacturing or developing flow cytometry products in the U.S. and worldwide. Additionally, this review provides detailed tables, charts and figures with past and projected sales data by geographic region for North America, Europe, Asia-Pacific and the emerging BRIC (Brazil, Russia, India and China) markets.

 

TABLE OF CONTENTS

1. Overview 8
1.1 Statement of Report 8
1.2 About This Report 9
1.3 Scope of the Report 10
1.4 Methodology 10

2. Executive Summary 13
2.1 Global Flow Cytometry Market Projected to Reach $5.9 Billion by 2020 13
2.2 Three Major Companies Command Over Half the Global Flow Cytometry Market 13
2.3 Reagents and Consumables are the Fastest Growing Product Group 13
2.4 Flow Cytometry will Advance Research and Development of New Cellular Therapies, Biologics and Vaccines 14
2.5 There is an Urgent Need for Point of Care Flow Cytometry in Resource Limited Countries 14

3. Market Environment 16
3.1 Global Economic Uncertainty 16
3.2 Lower Healthcare Utilization 16
3.3 Reduced Government Funding for Life Science Research 16
3.4 Consolidation of the Pharmaceutical Industry and Outsourcing to CROs 16
3.5 Global Aid to Resource Limited Countries 17

4. Flow Cytometry is a Dynamic Market 18
4.1 Market Leaders Strengthen their Dominant Position 18
4.2 Trends in the Global Flow Cytometry Market 19
4.2.1 More Lasers, More Fluorescent Dyes, More Data 19
4.2.2 Personal Flow Cytometers Moving Flow Cytometry Out of Core Laboratories 19
4.2.3 High Throughput Screening and Clinical Diagnostic Flow Cytometry Driving Workflow Automation 20
4.2.4 Portable POC Flow Cytometry Bringing CD4 Testing to Clinics and Remote Areas in Resource Limited Countries 20
4.2.5 Cell Sorters are Scaled Up for Clinical Scale Cell Sorting 20
4.3 Growth Opportunities in the Global Flow Cytometry Market 20
4.3.1 Microfluidics, Next Generation Cell Analysis and Sorting 20
4.3.2 Integrating Complementary Technologies Enable New Applications 21
4.3.3 A Gap and Challenge for Computational Data Analysis 21
4.3.4 High Growth Applications in Applied Markets Require Specialty Flow Cytometers 22
4.4 Strategic Considerations 22
4.4.1 The Flow Cytometry Market is Highly Competitive 22
4.4.2 County to Country Dynamics Impact International Operations 23
4.4.3 Governments are the Largest Funders of Life Science Research 23
4.4.4 Reimbursement for Clinical Diagnostics Impacts Acceptance of New Tests 23

5. The Global Flow Cytometry Market 25
5.1 Projected Global Flow Cytometry Market Revenue Through 2020 25
5.2 Market Drivers 25
5.3 Market Restrictors 26

6. Flow Cytometry Users 28
6.1 Pharmaceutical, Biotechnology, CROs 28
6.2 Clinical Diagnostic 28
6.3 Academic, Government, Private Foundations 29
6.4 Applied Science 29

7. Flow Cytometry Market Competitive Landscape 30
7.1 Competitors and Market Share 30
7.2 Key Players 31
7.2.1 BD Biosciences 31
7.2.2 Beckman Coulter 36
7.2.3 Thermo Fisher Scientific 41
7.2.4 Luminex Corporation 45
7.2.5 MilliporeSigma 49
7.2.6 Sysmex 53
7.2.7 Miltenyi Biotec 56

8. Global Flow Cytometry Market Analysis by Product 59
8.1 Projected Flow Cytometry Revenue by Product 59
8.2 Projected Flow Cytometry Instrument Revenue 63
8.2.1 Competitive Features of Flow Cytometry Instruments 64
8.2.1.1 High Performance Multicolor Flow Cytometers 64
8.2.1.2 Compact Flow Cytometers 67
8.2.1.3 Handheld Flow Cytometers 68
8.2.1.4 Cell Sorters 69
8.2.1.5 Flow Cytometry Imaging Systems 72
8.2.1.6 Mass Cytometry Systems 72
8.2.1.7 Multiplex Bead Flow Cytometry Systems 73
8.2.1.8 Flow Cytometry End-to-End Workflow Solutions 74
8.2.1.9 Considerations when Purchasing a Flow Cytometry Instrument 75
8.3 Projected Flow Cytometry Reagents and Consumables Revenue 76
8.3.1 Selecting Flow Cytometry Reagents 76
8.3.2 Leading Flow Cytometry Reagent Suppliers 78
8.4 Flow Cytometry Software and Bioinformatics Developers 79

9. Global Flow Cytometry Market Analysis by Region 82
9.1 Projected Flow Cytometry Market Revenue by Region 82
9.2 North America Flow Cytometry Market 84
9.2.1 North American Flow Cytometry Market Projected Revenue 84
9.2.2 Research Segment 85
9.2.3 Pharmaceutical and Biotechnology Segment 86
9.2.4 Clinical Diagnostics Segment 87
9.3 Western Europe Flow Cytometry Market 88
9.3.1 Western Europe Flow Cytometry Market Projected Revenue 88
9.3.2 Research Segment 89
9.3.3 Pharmaceutical and Biotechnology Segment 90
9.3.4 Clinical Diagnostics Segment 90
9.4 Asia-Pacific Flow Cytometry Market 91
9.4.1 Asia-Pacific Flow Cytometry Market Projected Revenue 91
9.4.2 Research Segment 91
9.4.3 Pharmaceutical and Biotechnology Segment 91
9.4.4 Clinical Diagnostics Segment 92
9.5 Emerging High Growth Markets 92
9.5.1 Emerging High Growth Markets Projected Revenue 92
9.5.2 China Flow Cytometry Market 95
9.5.2.1 China Market Projected Revenue 95
9.5.2.2 Research Segment 95
9.5.2.3 Pharmaceutical and Biotechnology Segment 96
9.5.2.4 Clinical Diagnostics Segment 96
9.5.3 India Flow Cytometry Market 97
9.5.3.1 India Market Projected Revenue 97
9.5.3.2 Research Segment 97
9.5.3.3 Pharmaceutical and Biotechnology Segment 98
9.5.3.4 Clinical Diagnostics Segment 98
9.5.4 Brazil Flow Cytometry Market 99
9.5.4.1 Brazil Market Projected Revenue 99
9.5.4.2 Research Segment 99
9.5.4.3 Pharmaceutical and Biotechnology Segment 100
9.5.4.4 Clinical Diagnostics Segment 100
9.5.5 Russian Federation, Central and Eastern Europe Flow Cytometry Market 100

10. The POC Flow Cytometry Market in Resource Limited Countries 102
10.1 Global Response to AIDS Epidemic Rapidly Increasing Demand for CD4 Testing 102
10.2 Clinics in Rural Regions do not have CD4 Testing Capability 103
10.3 Tiered Laboratory System in Resource Limited Countries 104
10.4 The Flow Cytometry and POC Flow Cytometry Market Projected Revenue, 2015-2020 104
10.5 The Global Flow Cytometry and POC Flow Cytometry Market by Region 107
10.5.1 The Flow Cytometry and POC Flow Cytometry Market Revenue by Region 107
10.5.2 South Africa POC Flow Cytometry Market 109
10.5.3 Nigeria POC Flow Cytometry Market 109
10.5.4 India POC Flow Cytometry Market 110
10.5.5 China POC Flow Cytometry Market 110
12.5.6 Russian Federation, Eastern Europe and Central Asia POC Flow Cytometry Market 111
10.5.7 Latin America POC Flow Cytometry Market 111
10.6 Competitors in the Flow Cytometry and POC Flow Market in Resource Limited Countries 112
10.6.1 Competitor’s Flow Cytometry Flow Cytometers and POC Flow Cytometry Analyzers 113

11. Recent Industry Developments, 2014-2016 117

12. Flow Cytometry Applications 123
12.1 Research Applications 123
12.1.1 Cell Signaling 123
12.1.2 Cell Proliferation 123
12.1.3 Cell Viability 124
12.1.4 Apoptosis 124
12.1.5 Cell Cycle Analysis 124
12.1.6 Intracellular Ion Measurement 124
12.1.7 Single Cell Gene Expression Analysis 125
12.1.8 Immunology and Immunotherapy 125
12.1.9 Stem Cell Research 126
12.1.10 Microbiology 127
12.2 Clinical Diagnostics 128
12.2.1 Regulatory Control of Flow Cytometry Clinical Diagnostic Applications 128
12.2.2 CD4 Lymphocyte Count 128
12.2.3 Immunophenotyping Leukemias and Lymphomas 129
12.2.4 Minimum Residual Disease 129
12.2.5 Anti-Neutrophil Antibody Detection in Auto-Immune and Immunodeficiency Disease 129
12.2.6 Platelet-Associated Immunoglobulin Assays 129
12.2.7 Reticulocyte Count 130
12.2.8 HLA Crossmatching and Cell Analysis for Stem Cell and Organ Transplantation 130
12.2.9 Paroxysmal Nocturnal Hemoglobinuria 130
12.2.10 Clinical Microbiology 131
12.3 Pharmaceutical and Biopharmaceutical Drug Discovery and Development 131
12.3.1 Drug Discovery and High Throughput Flow Cytometry 131
12.3.2 Preclinical Toxicology and Safety 132
12.3.3 Biomarkers and Drug Development 132
12.3.4 GMP Manufacture of Biologicals 133
12.3.5 Vaccine Development 133
12.4 Global Health 134
12.4.1 HIV/AIDS, Malaria, Tuberculosis 134
12.4.2 Tropical Medicine 134
12.5 Applied Sciences 135
12.5.1 Marine and Environmental Biology 136
12.5.2 Plant Biology 137
12.5.3 Veterinary Medicine 137
12.5.4 Food and Beverage Industry 138
12.5.5 BioDefense 138

13. Flow Cytometry Technology 139
13.1 Principle of Flow Cytometry 139
13.2 Fluidics 139
13.3 Optics 140
13.4 Electronics 141
13.5 Data Analysis 141
13.6 Cell Sorting 142
13.7 Labeling and Detection 142
13.8 Multiplex Bead Assays 143
13.9 Imaging Flow Cytometry 144
13.10 Mass Cytometry 145

14. New Flow Cytometry Technology 146
14.1 Microfluidics Flow Cytometry Technologies 146
14.2 Technologies for Rapid CD4 Testing 148

15. History of Flow Cytometry 150

16. Company Profiles 152
16.1 Abcam 152
16.2 Alere, Inc. 152
16.3 ALPCO Diagnostics 152
16.4 Apogee Flow Systems 152
16.5 Bangs Laboratories, a Division of Polysciences 153
16.6 Bay Bioscience 153
16.7 BD Biosciences (a Business Group within Becton Dickinson and Company (BD)) 153
16.8 Beckman Coulter (Business within Danaher) 154
16.9 Bio-Rad Laboratories 155
16.10 BioVision 155
16.11 Cell Signaling Technology 156
16.12 Cira Discovery Sciences 156
16.13 Clarient Diagnostic Services, Inc. 156
16.14 Cytobank, Inc. 156
16.15 CytoBuoy, B.V 156
16.16 CytonomeST 156
16.17 Dako, an Agilent Technologies Company 157
16.18 DeNovo Software 157
16.19 Fluidigm Corporation 157
16.20 Handyem 158
16.21 IntelliCyt Corporation 158
16.22 Luminex Corporation 158
16.23 MBio Diagnostics 158
16.24 MilliporeSigma (Division of Merck KGaA Germany) 159
16.25 Miltenyi Biotec 160
16.26 Orflow Technologies 160
16.27 Sysmex 160
16.28 PointCare Technologies 161
16.29 Promega Corporation 161
16.30 R&D Systems (Techne Corporation) 161
16.31 Santa Cruz Biotechnology 162
16.32 Soft Flow Hungary, Ltd. 162
16.33 Sony Biotechnology, Inc. 162
16.34 SouthernBiotech 162
16.35 Spherotech 162
16.36 Stratedigm 162
16.37 TaKaRa Clontech 162
16.38 Thermo Fisher Scientific 163
16.39 Tree Star 164
16.40 TTP LabTech 164
16.41 Union Biometrica 164
16.42 United States Biological Life Sciences 164
16.43 Verity Software House 165

17. Acronyms Used in This Report 166

INDEX OF FIGURES

Figure 6.1: Flow Cytometry Market by Laboratory Type, 2015 28
Figure 7.1: Flow Cytometry Competitors’ Market Share, 2015 31
Figure 8.1: Flow Cytometry Market Distribution by Product Revenue, 2015 60
Figure 8.2: Flow Cytometry Market Distribution by Product Revenue, 2020 60
Figure 8.3: Projected Flow Cytometry Revenue Growth by Product (CAGR), 2014-2020 61
Figure 9.1: Global Flow Cytometry Market Revenue by Region, 2015 83
Figure 9.2: Projected Flow Cytometry Market Revenue by Region, 2014-2020 83
Figure 9.3: Flow Cytometry Projected Growth Rate by Region, CAGR 2014-2020 84
Figure 9.4: Western Europe Flow Cytometry Market by Country, 2015 89
Figure 9.5: Emerging High Growth Countries Projected Flow Cytometry Revenue by Country, 2014-2020 94
Figure 9.6: Emerging Countries Flow Cytometry Revenue Share by Country, 2015 94
Figure 9.7: Emerging Countries Flow Cytometry Market Share by Country, 2020 95
Figure 10.1: CD4 Flow Cytometry Product Revenue Projection, 2014-2020 105
Figure 10.2: Flow Cytometry and POC Market Revenue by Region, 2015 108
Figure 10.3: Competitor’s Share by Revenue, CD4 Flow Cytometry, 2015 112
Figure 10.4: Market Share, CD4 Counting Instruments in Middle- to Low-Income Countries, 2013 112
Figure 13.1: Schematic of a Flow Cell 139
Figure 13.2: Schematic of a Flow Cytometer Optical Layout 140
Figure 13.3: Example of a Dot Plot of Lysed Whole Blood 141
Figure 13.4: Fluorescence Intensity Histogram 142
Figure 13.5: Principle of Multiplex Bead Assay 144


INDEX OF TABLES

Table 5.1: Flow Cytometry Projected Market Revenue, 2014-2020 25
Table 5.2: Flow Cytometry Market Drivers 26
Table 5.3: Flow Cytometry Market Restrictors 27
Table 7.1: BD Biosciences Flow Cytometry Product Line 33
Table 7.2: BD Biosciences Flow Cytometry Branded Reagents 35
Table 7.3: Beckman Coulter Flow Cytometry Product Line 38
Table 7.4: Beckman Coulter Branded Flow Cytometry Kits and Reagents 40
Table 7.5: Thermo Fisher Scientific Flow Cytometry Reagents 43
Table 7.6: Thermo Fisher Scientific Flow Cytometry Instruments 44
Table 7.7: Luminex Instruments for Multiple Assay Analysis 47
Table 7.8: Luminex Branded Multiplex Assays and Reagents 48
Table 7.9: MilliporeSigma Flow Cytometry Platforms 51
Table 7.10: MilliporeSigma Flow Cytometry Instruments, Kits, Reagents 52
Table 7.11: Sysmex Partec Flow Cytometry Product Line 55
Table 7.12: Sysmex Partec Flow Cytometry Instruments 55
Table 7.13: Sysmex Partec Reagents and Kits 55
Table 7.14: Miltenyi Biotec Cell Separation Products 58
Table 7.15: Miltenyi Biotec Flow Cytometry Product Line 58
Table 8.1: Flow Cytometry Projected Revenue by Product, 2014-2020 60
Table 8.2: Suppliers of Flow Cytometry Instruments, Reagents and Software 61
Table 8.3: Features: High Performance Multicolor Flow Cytometers 64
Table 8.4: Compact Flow Cytometers 67
Table 8.5: Handheld Flow Cytometers 69
Table 8.6: Features: Cell Sorters 69
Table 8.7: Mass Cytometry Technology Features 73
Table 8.8: Multiplex Instrument Features 73
Table 8.9: Considerations when Selecting a Flow Cytometer 76
Table 8.10: Manufacturers of Flow Cytometry Antibodies, Fluorophores, Kits, Reagents, Sample Prep 78
Table 8.11: Flow Cytometry Software Developers 80
Table 9.1: Projected Flow Cytometry Market Revenue by Region, 2014-2020 83
Table 9.2: Flow Cytometry Projected Growth Rate by Region, CAGR 2014-2020 84
Table 9.3: North America Flow Cytometry Market Projected by Product, 2014-2020 84
Table 9.4: NIH Historical Appropriations, 2008-2016 85
Table 9.5: NIH Funding for Selected Disease Categories, 2016 85
Table 9.6: Flow Cytometry Systems in NIH Flow Cytometry Core Facilities 86
Table 9.7: CROs Specializing in Flow Cytometry Services 86
Table 9.8: Western Europe Flow Cytometry Market Projected by Product, 2014-2020 88
Table 9.9: Asia-Pacific Flow Cytometry Projected Market by Product, 20143-2020 91
Table 9.10: Emerging High Growth Countries Projected Flow Cytometry Revenue, 2014-2020 93
Table 10.1: Population of People Living with HIV/AIDS, 2014 102
Table 10.2: Projected Number of People Accessing ART Under the UNAIDS Fast-Track Strategy,
2014-2020 103
Table 10.3: Optimal Features of a POC CD4 Test 103
Table 10.4: Flow Cytometry and POC Flow Cytometry Market Revenue, 2014-2020 105
Table 10.5: CD4 Flow Cytometry Product Revenue Projection, 2014-2020 106
Table 10.6: CD4 Flow Cytometry and POC Cytometry Market Drivers and Restrictors 107
Table 10.7: Global Distribution of People Living with HIV by Country 108
Table 10.8: Flow Cytometry and POC Flow Cytometry Market Revenue by Region, 2015 109
Table 10.9: CD4 Platforms for Resource Limited Countries 115
Table 12.1: Cell Types, Proteins and Microbes Detected by Flow Cytometry 123
Table 12.2: Flow Cytometry Applications in Stem Cell Research 126
Table 12.3: Microorganisms Detected by Flow Cytometry 127
Table 12.4: Flow Cytometry Clinical Diagnostic Applications 128
Table 12.5: Advantages of Flow Cytometry for High Throughput Screening 131
Table 12.6: Flow Cytometry Applications for Preclinical Toxicology and Safety 132
Table 12.7: NIH Definition of Biomarkers 133
Table 12.7: Neglected Tropical Diseases 135
Table 12.8: Flow Cytometry Products for Applied Markets 135
Table 13.1: Common Fluorophores Used in Flow Cytometry 143
Table 15.1: Differences between Hematology Analyzers and Flow Cytometers 150
Table 15.2: Flow Cytometry Timeline 151
Table 20.1: List of Acronyms Used in this Report 166

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