Loading... Please wait...

Global Flow Cytometry Markets

Bookmark and Share
Price:
$3,400.00
Publication Date:
May 2014; Pages: 158
File Type:
Downloadable PDF


Description



Global Flow Cytometry Sample

Flow cytometry is a laboratory analytical technique that can rapidly measure multiple parameters of individual cells or particles as they pass through a beam of light, typically a laser. The global flow cytometry market remains one of the fastest-growing segments of life sciences and clinical diagnostics markets. In the current life sciences research, pharmaceutical drug discovery and development, and clinical diagnostics markets, flow cytometry offers some of the brightest promise for growth and innovation. The purpose of this TriMark Publications report is to provide a detailed analysis of the global flow cytometry market, including size, growth, technology platforms, applications, new instrumentation, industry trends and the internal structure of the sector. The study covers highly attractive growth areas such as stem cell research, biomarkers and companion diagnostics, CD4 testing, high throughput screening and immunology and vaccine development. It also analyzes almost all of the companies known to be marketing, manufacturing or developing flow cytometry products in the U.S. and worldwide. Additionally, this review provides detailed tables, charts and figures with past and projected sales data by geographic region for North America, Europe, Asia-Pacific and the emerging BRIC (Brazil, Russia, India and China) markets.

 

TABLE OF CONTENTS

1. Overview 9
1.1 Statement of Report 9
1.2 About This Report 10
1.3 Scope of the Report 11
1.4 Methodology 11
1.5 Executive Summary 12
1.5.1 The Global Picture 12
1.5.2 Two Major Companies Dominate the Market 13
1.5.3 Reagents and Consumables Are the Fastest Growing Product Group 13
1.5.4 The HIV/AIDS Epidemic Has Created a Market for Point-of-Care Flow Cytometry 14
1.5.5 Flow Cytometry Will Advance Research and Development of New Cellular Therapies, Biologics
and Vaccines 14

2. Background and Development 16

3. Market Overview 18
3.1 Technology and Products 18
3.2 Market Environment 19
3.2.1 Global Economic Uncertainty 19
3.2.2 Lower Healthcare Utilization 20
3.2.3 Reduced Government Funding for Life Science Research 20
3.2.4 Consolidation of the Pharmaceutical Industry 20
3.2.5 Global Aid to Resource Limited Countries 20

4. Global Flow Cytometry Market 2013-2018 21
4.1 Global Flow Cytometry Market Size 21
4.2 Market Drivers 21
4.3 Market Restrictors 22
4.4 Flow Cytometry Market by User 23
4.4.1 Overview 23
4.4.2 Academic and Government Research Laboratories 23
4.4.3 Pharmaceutical and Biotechnology Companies 23
4.4.4 Hospital and Reference Clinical Laboratories 24
4.4.5 Niche Laboratories 24

5. Flow Cytometry Projected Revenue by Product. 2013-2018 25
5.1 Instruments and Service 26
5.2 Reagents and Consumables 26
5.3 Software 26

6. Market Analysis by Region 28
6.1 Market Size by Region 28
6.2 Developed Markets 30
6.2.1 North America 31
6.2.2 Western Europe 34
6.2.3 Asia-Pacific 37
6.3 Emerging Countries 38
6.3.1 Emerging Countries Projected Flow Cytometry Market 38
6.3.2 China 41
6.3.3 India 43
6.3.4 Brazil 44
6.3.5 Russia 46
6.4 Resource Limited Countries 47

7. Technology 48
7.1 Principle of Flow Cytometry 48
7.2 Fluidics 48
7.3 Optics 48
7.4 Electronics 49
7.5 Data Analysis 50
7.6 Cell Sorting 51
7.7 Labeling and Detection 51
7.8 Multiplex Bead Assays 52
7.9 Imaging Flow Cytometry 53

8. Applications 54
8.1 Research Applications 54
8.1.1 Detection of Cell Signaling Pathways in Single Cells 54
8.1.2 Cell Proliferation 54
8.1.3 Cell Viability 55
8.1.4 Apoptosis 55
8.1.5 Cell Cycle, DNA Content, Gene Expression 55
8.1.6 Multiplex Bead Assays 55
8.1.7 Stem Cell Research 56
8.1.8 Immunology Research and Vaccine Development 57
8.2 Clinical Diagnostics 57
8.2.1 Monitoring T-Cell Markers 58
8.2.2 Immunophenotyping of Leukemias and Lymphomas 58
8.2.3 Detection of Minimum Residual Disease 58
8.2.4 Anti-Neutrophil Antibody Detection in Auto-Immune and Immunodeficiency Disease 58
8.2.5 Platelet Associated Immunoglobulin Assays 58
8.2.6 Reticulocyte Count 59
8.2.7 HLA Crossmatching and Cell Analysis for Stem Cell and Organ Transplantation 59
8.2.8 Paroxysmal Nocturnal Hemoglobinuria 59
8.3 Pharmaceutical Applications 60
8.3.1 Biomarkers and Companion Diagnostics 60
8.3.2 Drug Discovery and High Throughput Screening 60
8.3.3 Toxicology 61
8.3.4 GMP Manufacture of Cellular Therapeutics 61
8.4 Global Health 62
8.4.1 Parasitic Diseases and Tropical Medicine 62
8.4.2 HIV/AIDS, Malaria and Tuberculosis 63
8.5 Niche Applications 63
8.5.1 Marine Biology 64
8.5.2 Plant Biology, Agriculture and Veterinary Medicine 65
8.5.3 Microbiology 65
8.5.4 Clinical Microbiology 65
8.5.5 Industrial Microbiology 66
8.5.6 Monitor Fermentation Processes 66
8.5.7 Monitor Water Quality 66
8.5.8 Screening Raw Materials and Finished Product 66

9. Flow Cytometry Instruments 67
9.1 High Performance Multicolor Analyzers 67
9.2 Midsize Flow Cytometers 68
9.3 Compact Flow Cytometers 69
9.4 Cell Sorters 70
9.5 Flow Cytometry Imaging Systems 72
9.6 High Throughput and Automated Systems 72
9.7 Multiplex Systems 73
9.8 Considerations When Purchasing a Flow Cytometry Instrument 73
9.9 Pricing 74

10. Flow Cytometry Reagents 75
10.1 Leading Suppliers of Reagents and Kits 75
10.2 Reagent Selection 75

11. Software and Bioinformatics 77

12. Competitive Landscape 79
12.1 Competitors and Market Share 79
12.2 Key Players 84
12.2.1 BD Biosciences 85
12.2.2 Beckman Coulter 88
12.2.3 Life Technologies 91
12.2.4 Luminex Corporation 92
12.2.5 EMD Millipore (Division of Merck KGaA) 95
12.2.6 Partec GmbH 97
12.2.7 Miltenyi Biotec 99
12.2.8 Affymetrix eBioscience 101

13. Industry Analysis 103
13.1 Trends 103
13.1.1 More Lasers, More Fluorescent Dyes, More Data 103
13.1.2 Moving Flow Cytometry Out of Core Laboratories 103
13.1.3 Higher Throughput 103
13.1.4 Clinical Scale Cell Sorting 103
13.1.5 Point-of-Care Flow Cytometry 103
13.2 Recent Industry Developments, 2011-2013 103

14. Innovation and New Technology 113
14.1 Cell-Analyzing Bio Chips for Point-of-Care Testing. 113
14.2 Microchip Based Disposable Cell Sorting Technology 113
14.3 Microfluidic Cell Sorter with Integrated Piezoelectric Actuator 113
14.4 On-Chip Sorting Using Acoustically Enhanced Magnetophoresis 113
14.5 NanoCytometry 113
14.6 Micro-Fabricated Fluorescence-Activated Cell Sorter 114
14.7 Flow Cytometry and a Cell Phone 114
14.8 Disposable Devices for CD4 T-Cell Enumeration 114
14.9 Non-Invasive Technique for Cytometric Analysis of Whole Blood 114
14.10 Innovative Startup Companies 115
14.10.1 Nanostring Technologies, Inc. 115
14.10.2 NanoCellect Biomedical, Inc. 115
14.10.3 Lamprogen 115

15. Gaps and Challenges 116
15.1 Software 116
15.2 Point-of-Care Flow Cytometry 116

16. Opportunities 117
16.1 Integrating Complementary Technologies 117
16.2 Automated Compound Screening 117
16.3 Specialized Flow Cytometers 117
16.4 Veterinary Testing 117
16.5 Marine Biology Systems 117
16.6 Plant Biology 117

17. Strategic Recommendations 118
17.1 Competing in the Flow Cytometry Market 118
17.2 International Operations Risks 118
17.3 Dependence on Government Funding and Healthcare Reform 118
17.4 Reimbursement for Clinical Diagnostics 119

18. The Point-of-Care Flow Cytometry Market 120
18.1 Introduction 120
18.2 Clinical Significance of the CD4 Test 120
18.3 Users 121
18.4 The Market Situation 122
18.5 The Regional Picture 123
18.5.1 Sub-Saharan Africa 124
18.5.2 India 125
18.5.3 Russia, Eastern Europe, Central Asia 126
18.5.4 China 126
18.5.5 Brazil 127
18.6 Market Projections 2013-2018 127
18.7 Competitive Landscape 130
18.8 Gaps and Challenges 133
18.8.1 Gaps 133
18.8.2 Challenges 134
18.9 Point-of-Care Flow Cytometry Innovation and New Technology 135
18.9.1 Immunochromatography 135
18.9.2 Cell Stacking/Sedimentation 135
18.9.3 Affinity Chromatography and Lysate Impedance Spectroscopy 135
18.9.4 Fluorescence Assay Illumination 135
18.9.5 Microchip Imaging Cytometry 135
18.9.6 Flow Cytometry and a Cell Phone 136
18.10 Point-of-Care Flow Cytometry Recent Industry Developments 136

19. Company Profiles 138
19.1 Abcam 138
19.2 Affymetrix eBioscience 138
19.3 Alere, Inc. 140
19.4 ALPCO Diagnostics 141
19.5 Apogee Flow Systems 141
19.6 Bangs Laboratories 141
19.7 Bay Bioscience 142
19.8 BD Biosciences 142
19.9 Beckman Coulter (Danaher) 143
19.10 Biocytex (Stago Group) 147
19.11 Bio-Rad Laboratories 147
19.12 BioVision 148
19.13 Cell Signaling Technology 148
19.14 Cira Discovery Sciences 148
19.15 Clarient (GE Healthcare) 148
19.16 Cytobank, Inc. 148
19.17 CytonomeST 148
19.18 Dako A/S 149
19.19 DVS Sciences, Inc. 149
19.20 IntelliCyt Corporation 149
19.21 Life Technologies 149
19.22 Luminex 151
19.23 EMD Millipore (Division of Merck KGaA Germany) 151
19.24 MBio Diagnostics 152
19.25 Miltenyi Biotec 152
19.26 Mindray 152
19.27 MiraiBio Group (Part of Hitachi Solutions America) 152
19.28 Nihon Kohden 153
19.29 Partec GmbH 153
19.30 PointCare Technologies 153
19.31 Promega Corporation 153
19.32 Propel Labs 153
19.33 R & D Systems (Techne Corporation) 153
19.34 Santa Cruz Biotechnology 154
19.35 Sigma-Aldrich 154
19.36 Soft Flow Hungary, Ltd. 154
19.37 Sony Biotechnology, Inc. 154
19.38 SouthernBiotech 154
19.39 Spherotech 155
19.40 Stratedigm 155
19.41 Sysmex 155
19.42 TaKaRa Bio 155
19.43 Thermo Fisher 156
19.44 Tree Star 156
19.45 TTP LabTech 156
19.46 Union Biometrica 157
19.48 U.S. Biological 157
19.49 Verity Software House 157

20. Acronyms Used in This Report 158


INDEX OF FIGURES

Figure 4.1: Flow Cytometry Market by User, 2013 24
Figure 5.1: Projected Market Growth by Flow Cytometry Product, 2013-2018 25
Figure 5.2: Flow Cytometry Market Distribution by Products, 2013 27
Figure 5.3: Flow Cytometry Market Distribution by Products, 2018 27
Figure 6.1: Global Flow Cytometry Market by Region, 2013 28
Figure 6.2: Global Flow Cytometry Market by Region, 2018 29
Figure 6.3: Five-Year Projected Flow Cytometry Market by Region, 2014-2018 29
Figure 6.4: Flow Cytometry Projected Growth Rate by Region, CAGR 2013-2018 30
Figure 6.5: Western Europe Flow Cytometry Market by Country, 2013 35
Figure 6.6: Emerging Countries Flow Cytometry Projected Market by Country, 2013-2018 39
Figure 6.7: Emerging Countries Flow Cytometry Market Share by Country, 2013 40
Figure 6.8: Emerging Countries Five-Year Growth Rate, CAGR 2013-2018 40
Figure 7.1: Schematic of a Flow Cell 48
Figure 7.2: Schematic of a Flow Cytometer Optical Layout 49
Figure 7.3: Example of a Dot Plot of Lysed Whole Blood 50
Figure 7.4: Fluorescence Intensity Histogram 51
Figure 7.4: Principle of Multiplex Bead Assay 53
Figure 12.1: Flow Cytometry Competitors’ Market Share, 2013 80
Figure 18.1: Global Distribution of HIV/AIDS Infected Persons Receiving Antiretroviral Therapy in Low-Middle Income Countries, 2012 122
Figure 18.2: Market Projection for POC Flow Cytometry in Middle to Low Income Countries, 2013-2018 128
Figure 18.3: Competitors’ Shares, Flow Cytometry and POC Instruments/Reagents/Consumables, 2013 130



INDEX OF TABLES

Table 2.1: Flow Cytometry Timeline 17
Table 3.1: Differences between Hematology Analyzers and Flow Cytometers 19
Table 3.2: Flow Cytometry Market Environment 19
Table 4.1: Flow Cytometry Projected Market Revenue, 2013-2018 21
Table 4.2: Flow Cytometry Market Drivers and Restrictors 23
Table 5.1: Flow Cytometry Projected Revenue by Product, 2013-2018 25
Table 5.2: Projected Market Growth by Flow Cytometry Product, 2013-2018 25
Table 6.1: Projected Flow Cytometry Market by Region, 2013-2018 29
Table 6.2: Flow Cytometry Projected Growth Rate by Region, CAGR 2013-2018 30
Table 6.3: North America Flow Cytometry Market Projected by Product, 2013-2018 31
Table 6.4: NIH Historical Spending, 2008-2012 32
Table 6.5: Flow Cytometry Systems in NIH Flow Cytometry Core Facilities 32
Table 6.6: CROs Specializing in Flow Cytometry Services 33
Table 6.7: Western Europe Flow Cytometry Market Projected by Product, 2013-2018 34
Table 6.8: Western Europe Flow Cytometry Market Projected by Country, 2013-2018 35
Table 6.9: Asia-Pacific Flow Cytometry Projected Market by Product, 2013-2018 37
Table 6.10: Emerging Countries Flow Cytometry Projected Market by Country, 2013-2018 39
Table 6.11: Emerging Countries Five-Year Growth Rate by Country, CAGR 2013-2018 40
Table 6.12: Emerging Countries Flow Cytometry Projected Market by Product, 2013-2018 41
Table 6.13: Resource Limited Countries Flow Cytometry Projected Market, 2013-2018 47
Table 7.1: Common Fluorophores Used in Flow Cytometry 52
Table 8.1: Cell Types, Proteins and Microbes Detected by Flow Cytometry 54
Table 8.2: Flow Cytometry Applications in Stem Cell Research 56
Table 8.3: Flow Cytometry Clinical Diagnostic Applications 57
Table 8.4: NIH Definition of Biomarkers 60
Table 8.5: Advantages of Flow Cytometry for High Throughput Screening 61
Table 8.6: Flow Cytometry Applications for Toxicology 61
Table 8.7: Neglected Tropical Diseases 62
Table 8.8: Flow Cytometers Products for Niche Applications 64
Table 8.9: Microorganisms Detected by Flow Cytometry 65
Table 9.1: Features: High Performance Analyzers 67
Table 9.2: Features: Midsize Analyzers for Research and Clinical IVD Applications 68
Table 9.3: Features: Midsize Analyzers for Research Applications 69
Table 9.4: Features: Compact Flow Cytometers 69
Table 9.5: Features: Cell Sorters 71
Table 9.6: Key Features of Multiplex Bead Systems 73
Table 9.7: Considerations When Selecting a Flow Cytometer 74
Table 12.1: Suppliers of Flow Cytometry Instruments, Reagents and Software 80
Table 12.2: North American Companies Participating in the Flow Cytometry Market 83
Table 12.3: Western European Companies Participating in the Flow Cytometry Market 84
Table 12.4: Asian Companies Participating in the Flow Cytometry Market 84
Table 12.5: BD Biosciences Selection of Flow Cytometry Instruments 87
Table 12.6: BD Biosciences Flow Cytometry Branded Reagents, Buffers and Solutions 88
Table 12.7: Beckman Coulter Flow Cytometry Instruments 89
Table 12.8: Beckman Coulter Branded Flow Cytometry Reagents 90
Table 12.9: Life Technologies Branded Flow Cytometry Reagents 92
Table 12.10: Luminex Instruments for Multiple Assay Analysis 94
Table 12.11: Luminex Branded Multiplex Assays and Reagents 95
Table 12.12: EMD Millipore Flow Cytometers 96
Table 12.13: EMD Millipore Brand Flow Cytometry Kits and Reagents 97
Table 12.14: Partec Flow Cytometry Instruments 98
Table 12.15: Partec Flow Cytometry Systems for Remote Testing 98
Table 12.16: Partec Reagents and Kits 99
Table 12.17: Miltenyi Biotec Branded Cell Separation and Flow Cytometry Products 100
Table 12.18: Affymetrix eBioscience Branded Reagents 102
Table 18.1: WHO Recommendations for the Use of Antiretroviral Drugs 121
Table 18.2: Global Distribution of HIV/AIDS Infected Persons Receiving Antiretroviral Therapy in Low-Middle Income Countries, 2012 123
Table 18.3: Top 12 Countries by Number of HIV/AIDS Infected Persons, 2012 124
Table 18.4: Market Projection for POC CD4 Systems in Middle to Low Income Countries, 2013-2018 128
Table 18.5: Point-of-Care Flow Cytometry Market Drivers and Restrictors 129
Table 18.6: CD4 Testing Platforms for Low to Middle Income Countries 132
Table 18.7: Optimal Features of a Point-of-Care CD4 Test System 134
Table 20.1: List of Acronyms Used in this Report 158

Find Similar Products by Category