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Global Flow Cytometry Markets

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$3,400.00
Publication Date:
June 2012; Pages: 112
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Flow cytometry is a laboratory analytical technique that can rapidly measure multiple parameters of individual cells or particles as they pass through a beam of light, typically a laser. The global flow cytometry market remains one of the fastest-growing segments of life sciences and clinical diagnostics markets. In the current life sciences research, pharmaceutical drug discovery and development, and clinical diagnostics markets, flow cytometry offers some of the brightest promise for growth and innovation. The purpose of this TriMark Publications report is to provide a detailed analysis of the global flow cytometry market, including size, growth, technology platforms, applications, new instrumentation, industry trends and the internal structure of the sector. The study covers highly attractive growth areas such as stem cell research, biomarkers and companion diagnostics, CD4 testing, high throughput screening and immunology and vaccine development. It also analyzes almost all of the companies known to be marketing, manufacturing or developing flow cytometry products in the U.S. and worldwide. Additionally, this review provides detailed tables, charts and figures with past and projected sales data by geographic region for North America, Europe, Asia-Pacific and the emerging BRIC (Brazil, Russia, India and China) markets.

 

TABLE OF CONTENTS

1. Overview 7
1.1 Statement of Report 7
1.2 About This Report 8
1.3 Objectives 9
1.4 Scope of the Report 10
1.5 Methodology 11
1.6 Executive Summary 13

2. Background and Development 15

3. Market Overview 17
3.1 Technology and Products 17
3.2 Market Environment 18
3.2.1 Global Economic Uncertainty 18
3.2.2 Lower Healthcare Utilization 18
3.2.3 Reduced Government Funding for Life Science Research 18
3.2.4 Consolidation of the Pharmaceutical Industry 18
3.2.5 Global Aid to Resource Limited Countries 19
3.3 Users 19
3.3.1 Overview 19
3.3.2 Research 19
3.3.3 Clinical 19
3.3.4 Pharmaceutical 19
3.3.5 Niche 20

4. Global Market Forecast 21
4.1 Overview 21
4.2 Market Drivers 21
4.3 Market Restrictors 22
4.4 Market by User 22

5. Product Forecast 23
5.1 Instrument Forecast 24
5.2 Reagents and Consumables Forecast 24
5.3 Software Forecast 25

6. The Global Market for CD4 T-Cell Testing 26

7. Market Analysis by Region 28
7.1 Overview 28
7.2 Developed Markets 29
7.2.1 North America 31
7.2.1.1 Research 31
7.2.1.2 Pharmaceutical 32
7.2.1.3 Clinical Diagnostics 33
7.2.2 Europe Flow Cytometry Market Analysis 34
7.2.2.1 Overview 34
7.2.2.2 Research 35
7.2.2.3 Pharmaceutical and Biotechnology 36
7.2.2.4 Clinical Diagnostics 36
7.2.3 Asia-Pacific 37
7.2.3.1 Overview 37
7.2.3.2 Research 37
7.2.3.3 Pharmaceutical and Biotechnology 37
7.2.3.4 Clinical Diagnostics 38
7.3 Emerging Markets 38
7.3.1 Overview 38
7.3.2 Brazil 40
7.3.2.1 Research 40
7.3.2.2 Clinical Diagnostics 41
7.3.2.3 Pharmaceutical 41
7.3.3 Russia 42
7.3.3.1 Overview 42
7.3.3.2 Research 42
7.3.3.3 Pharmaceutical and Biotechnology 43
7.3.3.4 Clinical Diagnostics 43
7.3.4 India 43
7.3.4.1 Overview 43
7.3.4.2 Research 43
7.3.4.3 Pharmaceutical and Biotechnology 44
7.3.4.4 Clinical Diagnostics 44
7.3.5 China 45
7.3.5.1 Overview 45
7.3.5.2 Research 45
7.3.5.3 Pharmaceutical and Biotechnology 46
7.3.5.4 Clinical Diagnostics 46
7.4 Resource Limited Countries 47

8. Technology 49
8.1 Principle of Flow Cytometry 49
8.2 Fluidics 49
8.3 Optics 49
8.4 Electronics 50
8.5 Data Analysis 51
8.6 Cell Sorting 52
8.7 Labeling and Detection 52
8.8 Multiplex Bead Assays 53
8.9 Imaging Flow Cytometry 54

9. Applications 55
9.1 Research Applications 55
9.1.1 Detection of Cell Signaling Pathways in Single Cells 55
9.1.2 Cell Proliferation 55
9.1.3 Cell Viability 56
9.1.4 Apoptosis 56
9.1.5 Cell Cycle, DNA Content, Gene Expression 56
9.1.6 Multiplex Bead Assays 56
9.1.7 Stem Cell Research 57
9.1.8 Immunology Research and Vaccine Development 58
9.2 Clinical Diagnostics 58
9.2.1 Monitoring T-Cell Markers 59
9.2.2 Immunophenotyping of Leukemias and Lymphomas 59
9.2.3 Detection of Minimum Residual Disease (MRD) 59
9.2.4 Anti-Neutrophil Antibody Detection in Auto-Immune and Immunodeficiency Disease 59
9.2.5 Platelet Associated Immunoglobulin Assays 59
9.2.6 Reticulocyte Count 60
9.2.7 HLA Crossmatching and Cell Analysis for Stem Cell and Organ Transplantation 60
9.2.8 Paroxysmal Nocturnal Hemoblobinuria 60
9.3 Pharmaceutical Applications 61
9.3.1 Biomarkers and Companion Diagnostics 61
9.3.2 Drug Discovery and High Throughput Screening 61
9.3.3 Toxicology 62
9.3.4 GMP Manufacture of Cellular Therapeutics 62

10. Global Health 64
10.1 Parasitic Diseases and Tropical Medicine 64
10.2 HIV/AIDS, Malaria and Tuberculosis 65

11. Niche Applications 66
11.1 Marine Biology 66
11.2 Plant Biology, Agriculture and Veterinary Medicine 67
11.3 Microbiology 67
11.3.1 Clinical Microbiology 67
11.3.2 Industrial Microbiology 68
11.4 Monitor Fermentation Processes 68
11.5 Monitor Water Quality 68
11.6 Screening Raw Materials and Finished Product 68

12. Flow Cytometry Products 69
12.1 Buying Decisions 69
12.2 Reagent Selection 69
12.3 Pricing 70
12.4 Instrument Key Features 71
12.4.1 High Performance Multicolor Analyzers 71
12.4.2 Cell Sorters 72
12.4.3 Compact Flow Cytometers for Individual Laboratories 73
12.4.4 Flow Cytometry Imaging Systems 75
12.4.5 High Throughput and Automated Systems 75
12.5 Multiplex Bead Systems 76
12.6 POC Instruments for CD4 Enumeration 76
12.7 Leading Suppliers of Reagents and Kits 77
12.8 Software and Bioinformatics 77

13. Competitive Analysis 82
13.1 Competitor Market Share 82
13.2 Competitive Landscape 82
13.2.1 Overview 82
13.2.2 Key Players 84
13.2.3 Products 85
13.3 Competitive Analysis of Key Players 86
13.3.1 BD Biosciences 86
13.3.2 Beckman Coulter 88
13.3.3 Life Technologies 89
13.3.4 Luminex Corporation 90
13.3.5 EMD Millipore 91
13.3.6 Partec 93
13.3.7 Miltenyi Biotec 94
13.3.8 Bioscience (a Division of Affymetrix) 94

14. Industry Analysis 95
14.1 Trends 95
14.1.1 More Lasers, More Fluorescent Dyes, More Data 95
14.1.2 Moving Flow Cytometry Out of Core Laboratories 95
14.1.3 Higher Throughput 95
14.1.4 Clinical Scale Cell Sorting 95
14.1.5 POC Flow Cytometry 95
14.2 Recent Industry Developments 95
14.3 Innovation and New Technology 98
14.3.1 Mass Cytometry 98
14.3.2 Micro-Fabricated Fluorescence-Activated Cell Sorter 98
14.3.3 Damage-Less Cell Sorting 99
14.3.4 Flow Cytometry and a Cell Phone 99
14.3.5 Disposable Devices for CD4 T-Cell Enumeration 99
14.4 Gaps and Challenges 99
14.4.1 Software 99
14.4.2 POC CD4 Testing 99
14.5 Opportunities 100
14.5.1 Integrating Complementary Technologies 100
14.5.2 Automated Compound Screening 100
14.5.3 Specialized Flow Cytometers 100
14.5.3.1 Veterinary Testing 100
14.5.3.2 Marine Biology Systems 100
14.5.3.3 Plant Biology 100
14.6 Strategic Recommendations 101
14.6.1 Competing in the Flow Cytometry Market 101
14.6.2 International Operations Risks 101
14.6.3 Dependence on Government Funding and Healthcare Reform 101
14.6.4 Reimbursement for Clinical Diagnostics 102

15. Company Profiles 103
15.1 AbD Serotec (part of MorphoSys) 103
15.2 ALPCO Diagnostics 103
15.3 Apogee Flow Systems 103
15.4 Bay Bioscience 103
15.5 BioCytex (Part of the Stago Group) 103
15.6 BioVision 104
15.7 Blue Ocean Medical 104
15.8 Cell Signaling Technology 104
15.9 Cira Discovery Sciences 104
15.10 Clarient 104
15.11 Cytobank, Inc. 104
15.12 CytonomeST 104
15.13 DVS Sciences, Inc. 104
15.14 iCyt Mission Technology 105
15.15 IntelliCyt Corporation 105
15.16 Miltenyi Biotec 105
15.17 Mindray 105
15.18 MiraiBio Group (Part of Hitachi Solutions America) 105
15.19 Nihon Kohden 106
15.20 Partec 106
15.21 PointCare Technologies 106
15.22 Promega Corporation 106
15.23 Santa Cruz Biotechnology 106
15.24 Sigma-Aldrich 107
15.25 Soft Flow 107
15.26 SouthernBiotech 107
15.27 Stratedigm 107
15.28 Sysmex 107
15.29 Takara Bio 108
15.30 Techne Corporation 108
15.31 Tree Star 108
15.32 TTP LabTech 108
15.33 Union Biometrica 109
15.34 U.S. Biological 109
15.35 Verity Software House 109

16. Acronyms Used in This Report 110


INDEX OF FIGURES

Figure 4.1: Market Share by Segment 22
Figure 5.1: Product Revenue Forecast, 2011-2017 23
Figure 5.2: Product Revenue Growth 24
Figure 5.3: Product Revenue Distribution 24
Figure 7.1: Global Flow Cytometry Market by Region 28
Figure 7.2: Five-Year Forecast by Region, 2011-2017 29
Figure 7.3: Annual Growth by Region 29
Figure 7.4: European Market Share by Country 35
Figure 7.5: Flow Cytometry Emerging Markets Forecast, 2011-2017 39
Figure 7.6: Emerging Market Share by Country, 2011 40
Figure 7.7: Growth Rate¬óEmerging Countries 40
Figure 8.1: Schematic of a Flow Cell 49
Figure 8.2: Schematic of a Flow Cytometer Optical Layout 50
Figure 8.3: Example of a Dot Plot of Lysed Whole Blood 51
Figure 8.4: Principle of Multiplex Bead Assay 54
Figure 13.1: Flow Cytometry Competitor’s Market Share 82


INDEX OF TABLES

Table 2.1: Flow Cytometry Timeline 16
Table 3.1: Differences between Hematology Analyzers and Flow Cytometers 17
Table 3.2: Flow Cytometry Market Environment 18
Table 4.1: Global Revenue Forecast, 2011-2017 21
Table 5.1: Product Revenue Forecast, 2011-2017 23
Table 6.1: Number of Adults and Children Living with HIV in 2010, Lower to Middle Income Countries 26
Table 6.2: Regional Antiretroviral Therapy Coverage 27
Table 7.1: Global Flow Cytometry Market Forecast by Region, 2011-2017 28
Table 7.2: NIH Funding for Stem Cell Research, 2011-2013 30
Table 7.3: North America Revenue Forecast, 2011-2017 31
Table 7.4: NIH Historical Spending, 2008-2012 31
Table 7.5: Flow Cytometry Systems in NIH Core Flow Cytometry Facilities 32
Table 7.6: CROs Specializing in Flow Cytometry Services 33
Table 7.7: European Product Forecast, 2011-2017 34
Table 7.8: European Revenue Forecast by Country, 2011-2017 34
Table 7.9: Asia-Pacific Revenue Forecast, 2011-2017 37
Table 7.10: Emerging Markets Product Revenue Forecast, 2011-2017 39
Table 7.11: Emerging Markets Revenue Forecast by Country, 2011-2017 39
Table 7.12: Resource Limited Markets. Product Revenue Forecast, 2011-2017 47
Table 8.1: Common Fluorophores Used in Flow Cytometry 53
Table 9.1: Cell Types, Proteins and Microbes Detected by Flow Cytometry 55
Table 9.2: Flow Cytometry Applications in Stem Cell Research 57
Table 9.3: Flow Cytometry Clinical Diagnostic Applications 58
Table 9.4: NIH Definition of Biomarkers 61
Table 9.5: Advantages of Flow Cytometry for High Throughput Screening 62
Table 9.6: Flow Cytometry Applications for Toxicology 62
Table 10.1: Neglected Tropical Diseases 64
Table 11.1: Flow Cytometers Products for Niche Applications 66
Table 11.2: Microorganisms Detected by Flow Cytometry 67
Table 12.1: Considerations When Selecting a Flow Cytometer 69
Table 12.2: Features: High Performance Analyzers 71
Table 12.3: Features: Cell Sorters 72
Table 12.4: Features: Compact Analyzers for Individual Laboratories 73
Table 12.5: Features: Midsize Analyzers for Clinical IVD Applications 74
Table 12.6: Features: MidSize Analyzers for Research Applications 75
Table 12.7: Multiplex Bead Systems. Key Features 76
Table 12.8: Suppliers of Flow Cytometry Instruments, Reagents and Software 79
Table 13.1: North American Companies Participating in the Flow Cytometry Market 83
Table 13.2: European Companies Participating in the Flow Cytometry Market 84
Table 13.3: Asian Companies Participating in the Flow Cytometry Market 84
Table 13.4: BD Biosciences Selection of Flow Cytometry Instruments 87
Table 13.5: Beckman Coulter Flow Cytometry Instruments 89
Table 13.6: Life Technologies Flow Cytometry Instruments 90
Table 13.7: Luminex Products 91
Table 13.8: Millipore Flow Cytometry Instruments 92
Table 13.9: Partec Flow Cytometry Instruments 93

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